Agentase, LLC is a technology company founded in December 1998 by Dr. Keith LeJeune and Dr. Alan Russell, two of the nation's leading experts on enzyme-polymer hybrid materials. The company possesses proprietary and patented technology in the synthesis and potential applications of enzyme containing polymers.

ALung Technologies, Inc. (the “Company”) develops intra and extracorporeal gas exchange devices for the treatment of acute and chronic respiratory disorders.  By directly delivering oxygen (O2) to the blood and removing carbon dioxide (CO2) from the blood, the company’s products deliver a clinically and economically superior ventilation solution than mechanical ventilation.  ALung products are capable of supporting patients with acute breathing problems for 7 days, providing their lungs a bridge to recovery.

Blue Belt Technologies, Inc., a Carnegie Mellon University spin-off company, was formed in 2003 to commercialize novel device solutions for medical interventions.  Blue Belt draws from the extensive experience of its research team to develop devices in computer-assisted surgery and diagnosis.  The company has developed Precision Freehand Sculpting™ (PFS), a solution that reintroduces robotics into the operating room to enable safer, faster, and more accurate treatment of osteoarthritis and other bone related conditions.  PFS will address the challenges of Minimally Invasive Surgery, with the goal of improving patient outcomes and lowering healthcare costs.

Cellatope is a cell analysis company that is developing research and diagnostic products and services in the field of autoimmune and inflammatory disease, with an initial focus on lupus and transplant medicine.  The Company’s technology platform – cell-bound complement activation products (CB-CAPs) – is the subject of an exclusive, world-wide license from the Universtiy of Pittsburgh (UPITT) and is based on research at the University of Pittsburgh Medical Center.

Cognition Therapeutics, Inc. is a biopharmaceutical company focused on developing novel therapies for neurodegenerative diseases such as Alzheimer’s. Cognition’s approach combines biological expertise around protein targets, proprietary assays that emphasize functional responses, and proprietary chemistry that insures novel, high quality small-molecule drug candidates.

Cohera Medical, Inc. is a medical device company aimed at fulfilling the market demand for a strong, safe, easy-to-use surgical adhesive to improve deep wound closure. Our first product, TissuGlue™ will be used to position tissues for optimal healing while reducing the need for fluid drains. The flexibility of our proprietary chemistry will allow us to generate a family of products that will address a variety of clinical needs for tissue fixation.

Crystalplex develops and commercializes innovative fluorescent markers for use in biological research and testing. Our technology is based on our proprietary composition-tunable nanocrystals (quantum dots). Our PLxBeadTM products enable researchers to collect multiple results simultaneously from very small sample volumes. PLxBeadsTM provide an easy-to-use solution to the cumbersome methods currently used to derive protein and genetic information. Crystalplex products promise to reduce the labor and shorten the time required for academic and pharmaceutical research.

Fluorous Technologies, Inc. (FTI) manufactures a variety of products that facilitate the use of fluorous chemistry in traditional and high-throughput synthesis. These products are marketed under the trade name FluoroFlash®, and include fluorous protecting groups, fluorous reagents for specific synthetic reactions, fluorous scavengers, fluorous building blocks, and fluorous sorbents in a variety of formats.

Health Monitoring Systems is a pioneer in community health surveillance. The company maintains online networks to collect data from hospitals and other healthcare providers, and then offers analytics of the aggregated information to detect, pinpoint and understand real-time and emerging health and safety issues. Clients include public health authorities, hospitals and others in the healthcare industry.

Immunetrics is a bio-simulation company, founded in 2001, that specializes in in silico disease modeling.  Immunetrics modeling technology provides critical information to drug developers to accelerate and improve the drug discovery and development process, particularly in the identification of clinically relevant biomarkers.   Immunetrics has developed a predictive software model of the human response to inflammation and coagulation, which enables drug discovery and development firms to gain comprehensive insights into a compound before investing significant resources into time-intensive and costly animal testing and human clinical trials.

KeyBay Pharma is dedicated to the discovery, development and commercialization of the next generation of novel antibiotics.

Knopp Neurosciences Inc. is a biotechnology company with a mission to accelerate the diagnosis and improve the treatment of amyotrophic lateral sclerosis (ALS), often called Lou Gehrig’s disease. Led by veteran executives from the pharmaceutical industry, Knopp is developing two synergistic technologies to address unmet needs in ALS: novel drug therapy to give patients a chance against the disease and molecular biomarkers to provide earlier diagnosis.

Diamyd, Inc. was formed through the acquisition of Nurel Therapeutics in December 2005 and is the wholly-owned US subsidiary of Diamyd Medical AB, a publicly traded company based in Stockholm, Sweden.  Diamyd Medical's lead product, Diamyd®, is a novel protein therapy for the prevention of the onset of diabetes and is currently in two Phase 2 clinical trials in Sweden.  At its Pittsburgh location, Diamyd is developing novel products for the treatment of diabetes and its complications including chronic pain and diabetic neuropathy.   Diamyd's proprietary nerve targeting delivery system was developed at the University of Pittsburgh and has numerous additional applications including potential therapies for the treatment of cancer and central nervous systems disorders.

PetsDx Veterinary Imaging, Inc. is an innovative group of individuals experienced in both veterinary medicine and magnetic resonance imaging (MRI). We are committed to working with local veterinarians to advance the practice of veterinary medicine by offering convenient access to state-of-the-art diagnostic technologies.

Proteopure develops cell preparation kits that enable proteomics researchers to achieve better, more reliable results.  Unlike competitor products, Proteopure's patent pending technology is the only protein isolation method that has a "hook" to capture proteins and is suitable for all sample types.  Proteomic scientists search cells, which can contain thousands of proteins for new biomarkers and drug targets.  However, proteome analysis techniques are sensitive to contaminants in the sample.  As a result, the need for better protein isolation tools is growing rapidly.

Based in Pittsburgh, PA, ReGear Life Sciences, Inc. develops and markets innovative deep-tissue therapeutic heating products consisting of comfortable body-part specific garments powered by a portable radio frequency (RF) generator. Therapeutic levels of warming have been proven to relieve pain, decrease joint stiffness, relieve muscle spasms, increase blood flow and range of motion and facilitate a healing response. The patented system has been cleared by the FDA for unattended use. Initial investors in ReGear include Pittsburgh Life Sciences Greenhouse and Innovation Works.

STARR Life Sciences' mission is to improve the efficacy of medical research by creating small-animal versions of human medical diagnostic and monitoring devices.  These parallel tools ensure that medical research results, obtained using mice and rats, improve the health of humans.  STARR's cornerstone product, the MouseOx(TM), is the world's first and only pulse oximeter for mice and rats.  The MouseOx is more than just a pulse oximeter.  It provides real-time measurements of pulse rate, blood flow, arterial oxygen saturation, breath rate and effort to breath all from one simple, easy to use, non-invasive sensor.

Thermal Therapeutic Systems Inc. is an early stage medical device company specifically created to address a very strategic opportunity in the marketplace relative to the treatment of advanced abdominal cancers using heat-activated chemotherapies.